TY - JOUR
T1 - The complex interplay between mitochondrial dynamics and cardiac metabolism
AU - Parra, Valentina
AU - Verdejo, Hugo
AU - Del Campo, Andrea
AU - Pennanen, Christian
AU - Kuzmicic, Jovan
AU - Iglewski, Myriam
AU - Hill, Joseph A.
AU - Rothermel, Beverly A.
AU - Lavandero, Sergio
N1 - Funding Information:
Acknowledgments This research was funded in part by the Comision Nacional de Ciencia y Tecnologia (FONDECYT 1080436 and FONDAP 15010006 to S.L.), the National Institutes of Health (RO1HL090842, RO1HL080144 and RO1 HL0755173 to J.A.H. and RO1HL072016 and RO1HL097768 to B.A.R.), the American Heart Association (10POST4340064 to M.I., 0640084N to J.A.H., and Gran-in-Aid #0655202Y to B.A.R.), the American Heart Association-Jon Holden DeHaan Foundation (to J.A.H. and B.A.R.). V.P., H.V., J.K., C.P., A.d.C. hold a PhD fellowship from CONICYT, Chile.
PY - 2011/2
Y1 - 2011/2
N2 - Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.
AB - Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.
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U2 - 10.1007/s10863-011-9332-0
DO - 10.1007/s10863-011-9332-0
M3 - Article
C2 - 21258852
AN - SCOPUS:79952313538
SN - 0145-479X
VL - 43
SP - 47
EP - 51
JO - Journal of Bioenergetics and Biomembranes
JF - Journal of Bioenergetics and Biomembranes
IS - 1
ER -