Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Carla M. Clark; Cynthia R. Driver; Sonal S. Munsiff; Jeffrey R. Driscoll; Barry N. Kreiswirth; Benyang Zhao; Adeleh Ebrahimzadeh; Max Salfinger; Amy S. Piatek; Jalaa' Abdelwahab; Tracy Agerton; Sara Beatrice; Roseann Costarella; Rafael Fernandez; Dolores Gallagher; Karen Granville; Natalia Kurepina; Fabienne Laraque; Jiehui Li; Michelle Macaraig; Barun Mathema; Lucille Palumbo; Linda Parsons; Alex Ravikovitch; Harry Taber; Rachel Wiseman; Genet Zickas

doi:10.3201/eid1205.050446

Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Carla M. Clark, Cynthia R. Driver, Sonal S. Munsiff, Jeffrey R. Driscoll, Barry N. Kreiswirth, Benyang Zhao, Adeleh Ebrahimzadeh, Max Salfinger, Amy S. Piatek, Jalaa' Abdelwahab, Tracy Agerton, Sara Beatrice, Roseann Costarella, Rafael Fernandez, Dolores Gallagher, Karen Granville, Natalia Kurepina, Fabienne Laraque, Jiehui Li, Michelle MacaraigBarun Mathema, Lucille Palumbo, Linda Parsons, Alex Ravikovitch, Harry Taber, Rachel Wiseman, Genet Zickas

Mailman School of Public Health

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

Original language	English
Pages (from-to)	719-724
Number of pages	6
Journal	Emerging Infectious Diseases
Volume	12
Issue number	5
DOIs	https://doi.org/10.3201/eid1205.050446
Publication status	Published - May 2006

Bibliographical note

Funding Information:
This study was financed within the framework of the 2012 CCM Program. CCM is the National Centre for Disease Prevention and Control whose task is to liaise with the Ministry of Health and the regional governments as far as surveillance and prevention are concerned and whose aim is to promptly respond to emergencies. http://www.ccm-network.it/progetto.jsp?id = node/ 1846&idP = 740.

ASJC Scopus Subject Areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3201/eid1205.050446

Cite this

Clark, C. M., Driver, C. R., Munsiff, S. S., Driscoll, J. R., Kreiswirth, B. N., Zhao, B., Ebrahimzadeh, A., Salfinger, M., Piatek, A. S., Abdelwahab, J., Agerton, T., Beatrice, S., Costarella, R., Fernandez, R., Gallagher, D., Granville, K., Kurepina, N., Laraque, F., Li, J., ... Zickas, G. (2006). Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003. Emerging Infectious Diseases, 12(5), 719-724. https://doi.org/10.3201/eid1205.050446

Clark, CM, Driver, CR, Munsiff, SS, Driscoll, JR, Kreiswirth, BN, Zhao, B, Ebrahimzadeh, A, Salfinger, M, Piatek, AS, Abdelwahab, J, Agerton, T, Beatrice, S, Costarella, R, Fernandez, R, Gallagher, D, Granville, K, Kurepina, N, Laraque, F, Li, J, Macaraig, M, Mathema, B, Palumbo, L, Parsons, L, Ravikovitch, A, Taber, H, Wiseman, R & Zickas, G 2006, 'Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003', Emerging Infectious Diseases, vol. 12, no. 5, pp. 719-724. https://doi.org/10.3201/eid1205.050446

@article{0c9ebab3e6954f42a67287c9474be7d0,

title = "Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003",

abstract = "In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.",

author = "Clark, {Carla M.} and Driver, {Cynthia R.} and Munsiff, {Sonal S.} and Driscoll, {Jeffrey R.} and Kreiswirth, {Barry N.} and Benyang Zhao and Adeleh Ebrahimzadeh and Max Salfinger and Piatek, {Amy S.} and Jalaa' Abdelwahab and Tracy Agerton and Sara Beatrice and Roseann Costarella and Rafael Fernandez and Dolores Gallagher and Karen Granville and Natalia Kurepina and Fabienne Laraque and Jiehui Li and Michelle Macaraig and Barun Mathema and Lucille Palumbo and Linda Parsons and Alex Ravikovitch and Harry Taber and Rachel Wiseman and Genet Zickas",

note = "Funding Information: This study was financed within the framework of the 2012 CCM Program. CCM is the National Centre for Disease Prevention and Control whose task is to liaise with the Ministry of Health and the regional governments as far as surveillance and prevention are concerned and whose aim is to promptly respond to emergencies. http://www.ccm-network.it/progetto.jsp?id = node/ 1846&idP = 740.",

year = "2006",

month = may,

doi = "10.3201/eid1205.050446",

language = "English",

volume = "12",

pages = "719--724",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "5",

}

TY - JOUR

T1 - Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

AU - Clark, Carla M.

AU - Driver, Cynthia R.

AU - Munsiff, Sonal S.

AU - Driscoll, Jeffrey R.

AU - Kreiswirth, Barry N.

AU - Zhao, Benyang

AU - Ebrahimzadeh, Adeleh

AU - Salfinger, Max

AU - Piatek, Amy S.

AU - Abdelwahab, Jalaa'

AU - Agerton, Tracy

AU - Beatrice, Sara

AU - Costarella, Roseann

AU - Fernandez, Rafael

AU - Gallagher, Dolores

AU - Granville, Karen

AU - Kurepina, Natalia

AU - Laraque, Fabienne

AU - Li, Jiehui

AU - Macaraig, Michelle

AU - Mathema, Barun

AU - Palumbo, Lucille

AU - Parsons, Linda

AU - Ravikovitch, Alex

AU - Taber, Harry

AU - Wiseman, Rachel

AU - Zickas, Genet

N1 - Funding Information: This study was financed within the framework of the 2012 CCM Program. CCM is the National Centre for Disease Prevention and Control whose task is to liaise with the Ministry of Health and the regional governments as far as surveillance and prevention are concerned and whose aim is to promptly respond to emergencies. http://www.ccm-network.it/progetto.jsp?id = node/ 1846&idP = 740.

PY - 2006/5

Y1 - 2006/5

N2 - In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

AB - In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

UR - http://www.scopus.com/inward/record.url?scp=33646549920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646549920&partnerID=8YFLogxK

U2 - 10.3201/eid1205.050446

DO - 10.3201/eid1205.050446

M3 - Review article

C2 - 16704826

AN - SCOPUS:33646549920

SN - 1080-6040

VL - 12

SP - 719

EP - 724

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this