TY - JOUR
T1 - Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003
AU - Clark, Carla M.
AU - Driver, Cynthia R.
AU - Munsiff, Sonal S.
AU - Driscoll, Jeffrey R.
AU - Kreiswirth, Barry N.
AU - Zhao, Benyang
AU - Ebrahimzadeh, Adeleh
AU - Salfinger, Max
AU - Piatek, Amy S.
AU - Abdelwahab, Jalaa'
AU - Agerton, Tracy
AU - Beatrice, Sara
AU - Costarella, Roseann
AU - Fernandez, Rafael
AU - Gallagher, Dolores
AU - Granville, Karen
AU - Kurepina, Natalia
AU - Laraque, Fabienne
AU - Li, Jiehui
AU - Macaraig, Michelle
AU - Mathema, Barun
AU - Palumbo, Lucille
AU - Parsons, Linda
AU - Ravikovitch, Alex
AU - Taber, Harry
AU - Wiseman, Rachel
AU - Zickas, Genet
N1 - Funding Information:
This study was financed within the framework of the 2012 CCM Program. CCM is the National Centre for Disease Prevention and Control whose task is to liaise with the Ministry of Health and the regional governments as far as surveillance and prevention are concerned and whose aim is to promptly respond to emergencies. http://www.ccm-network.it/progetto.jsp?id = node/ 1846&idP = 740.
PY - 2006/5
Y1 - 2006/5
N2 - In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.
AB - In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.
UR - http://www.scopus.com/inward/record.url?scp=33646549920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646549920&partnerID=8YFLogxK
U2 - 10.3201/eid1205.050446
DO - 10.3201/eid1205.050446
M3 - Review article
C2 - 16704826
AN - SCOPUS:33646549920
SN - 1080-6040
VL - 12
SP - 719
EP - 724
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -
