Elucidating the role of microglia and neurotrophin receptor p75 on neuronal degeneration in frontotemporal dementia

This study sets out to investigate the role of microglia and the neurotrophin receptor p75NTR on neuronal degeneration in frontotemporal dementia. We combine molecular analyses including single-nucleus RNA sequencing in postmortem brain tissue with a dynamic human stem cell model of frontotemporal dementia using patient-derived induced pluripotent stem cells. Co-culture assays, overexpression and knockdown of p75NTR as well as cell transplantation and single cell analyses will be performed to elucidate the mechanisms underlying this disease.