Integrating soft and hard tissues via interface tissue engineering

Sahishnu Patel, Jon Michael Caldwell, Stephen B. Doty, William N. Levine, Scott Rodeo, Louis J. Soslowsky, Stavros Thomopoulos, Helen H. Lu

Producción científicarevisión exhaustiva

101 Citas (Scopus)

Resumen

The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal, even post surgical intervention. Interface tissue engineering represents an integrative strategy for regenerating the native enthesis by functionally connecting soft and hard tissues and thereby improving clinical outcome. This review focuses on integrative and cell-instructive scaffold designs that target the healing of the two most commonly injured soft tissue-bone junctions: tendon-bone interface (e.g., rotator cuff) and ligament-bone interface (e.g., anterior cruciate ligament). The inherent connectivity between soft and hard tissues is instrumental for musculoskeletal motion and is therefore a key design criterion for soft tissue regeneration. To this end, scaffold design for soft tissue regeneration have progressed from single tissue systems to the emerging focus on pre-integrated and functional composite tissue units. Specifically, a multifaceted, bioinspired approach has been pursued wherein scaffolds are tailored to stimulate relevant cell responses using spatially patterned structural and chemical cues, growth factors, and/or mechanical stimulation. Moreover, current efforts to elucidate the essential scaffold design criteria via strategic biomimicry are emphasized as these will reduce complexity in composite tissue regeneration and ease the related burden for clinical translation. These innovative studies underscore the clinical relevance of engineering connective tissue integration and have broader impact in the formation of complex tissues and total joint regeneration.

Idioma originalEnglish
Páginas (desde-hasta)1069-1077
Número de páginas9
PublicaciónJournal of Orthopaedic Research
Volumen36
N.º4
DOI
EstadoPublished - abr. 2018

Financiación

FinanciadoresNúmero del financiador
DoD CDMRPW81XWH-15-1-0685
HHLR01-AR055280
National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin DiseasesR01AR055280
Harvard School of Engineering and Applied Sciences
New York State Stem Cell Science

    ASJC Scopus Subject Areas

    • Orthopedics and Sports Medicine

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