@article{842598d432334dd1b657a109918fe268,
title = "On the mechanism of hydrogen-deuterium exchange in bacteriorhodopsin",
abstract = "Continuous-flow resonance Raman experiments carried out in bacteriorhodopsin show that the exchange of a deuteron on the Schiff base with a proton takes place in times shorter than 3 ms. Exchange mechanisms based on a base-catalyzed deprotonation followed by reprotonation of the Schiff base are excluded. A mechanism is suggested in which a water molecule interacts directly with the Schiff base deuteron in a concerted exchange mechanism. It appears that in the dark, the binding site is more accessible to neutral water molecules than to charged protons.",
author = "Doukas, {A. G.} and A. Pande and T. Suzuki and Callender, {R. H.} and B. Honig and M. Ottolenghi",
note = "Funding Information: This work was supported in part by the National Science Foundation (PCM79-02683), by the National Institutes of Health (EY03142), by a City University PSC-BHE Faculty Award at the City College, and by the National Science Foundation (PCM80-1093 1) at the University of Illinois.",
year = "1981",
doi = "10.1016/S0006-3495(81)84889-8",
language = "English",
volume = "33",
pages = "275--279",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Biophysical Society",
number = "2",
}