Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso; César Vásquez-Trincado; Andrea Del Campo; Damián Gatica; Pablo E. Morales; Felipe Paredes; Natalia Torrealba; Camila Lopez-Crisosto; Zully Pedrozo; Lorena Garda; Guillermo Díaz-Araya; Pavan K. Battiprolu; Andriy Nemchenko; Anwarul Ferdous; Thomas G. Gillette; Joseph A. Hill; Sergio Lavandero

Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso, César Vásquez-Trincado, Andrea Del Campo, Damián Gatica, Pablo E. Morales, Felipe Paredes, Natalia Torrealba, Camila Lopez-Crisosto, Zully Pedrozo, Lorena Garda, Guillermo Díaz-Araya, Pavan K. Battiprolu, Andriy Nemchenko, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill, Sergio Lavandero

Universidad de Chile

Producción científica

Resumen

Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

Idioma original	English
Título de la publicación alojada	Autophagy
Subtítulo de la publicación alojada	Principles, Regulation and Roles in Disease
Editorial	Nova Science Publishers, Inc.
Páginas	181-194
Número de páginas	14
ISBN (versión impresa)	9781619422667
Estado	Published - 2012

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

ODS de las Naciones Unidas

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Troncoso, R., Vásquez-Trincado, C., Campo, A. D., Gatica, D., Morales, P. E., Paredes, F., Torrealba, N., Lopez-Crisosto, C., Pedrozo, Z., Garda, L., Díaz-Araya, G., Battiprolu, P. K., Nemchenko, A., Ferdous, A., Gillette, T. G., Hill, J. A., & Lavandero, S. (2012). Regulation of autophagy by insulin/IGF-1 signaling pathways. En Autophagy: Principles, Regulation and Roles in Disease (pp. 181-194). Nova Science Publishers, Inc..

Troncoso, R, Vásquez-Trincado, C, Campo, AD, Gatica, D, Morales, PE, Paredes, F, Torrealba, N, Lopez-Crisosto, C, Pedrozo, Z, Garda, L, Díaz-Araya, G, Battiprolu, PK, Nemchenko, A, Ferdous, A, Gillette, TG, Hill, JA & Lavandero, S 2012, Regulation of autophagy by insulin/IGF-1 signaling pathways. En Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., pp. 181-194.

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AU - Gatica, Damián

AU - Morales, Pablo E.

AU - Paredes, Felipe

AU - Torrealba, Natalia

AU - Lopez-Crisosto, Camila

AU - Pedrozo, Zully

AU - Garda, Lorena

AU - Díaz-Araya, Guillermo

AU - Battiprolu, Pavan K.

AU - Nemchenko, Andriy

AU - Ferdous, Anwarul

AU - Gillette, Thomas G.

AU - Hill, Joseph A.

AU - Lavandero, Sergio

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AB - Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

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Regulation of autophagy by insulin/IGF-1 signaling pathways

Resumen

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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