Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso; César Vásquez-Trincado; Andrea Del Campo; Damián Gatica; Pablo E. Morales; Felipe Paredes; Natalia Torrealba; Camila Lopez-Crisosto; Zully Pedrozo; Lorena Garda; Guillermo Díaz-Araya; Pavan K. Battiprolu; Andriy Nemchenko; Anwarul Ferdous; Thomas G. Gillette; Joseph A. Hill; Sergio Lavandero

Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso, César Vásquez-Trincado, Andrea Del Campo, Damián Gatica, Pablo E. Morales, Felipe Paredes, Natalia Torrealba, Camila Lopez-Crisosto, Zully Pedrozo, Lorena Garda, Guillermo Díaz-Araya, Pavan K. Battiprolu, Andriy Nemchenko, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill, Sergio Lavandero

Universidad de Chile

Résultat de recherche

Résumé

Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

Langue d'origine	English
Titre de la publication principale	Autophagy
Sous-titre de la publication principale	Principles, Regulation and Roles in Disease
Maison d'édition	Nova Science Publishers, Inc.
Pages	181-194
Nombre de pages	14
ISBN (imprimé)	9781619422667
Statut de publication	Published - 2012

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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Troncoso, R., Vásquez-Trincado, C., Campo, A. D., Gatica, D., Morales, P. E., Paredes, F., Torrealba, N., Lopez-Crisosto, C., Pedrozo, Z., Garda, L., Díaz-Araya, G., Battiprolu, P. K., Nemchenko, A., Ferdous, A., Gillette, T. G., Hill, J. A., & Lavandero, S. (2012). Regulation of autophagy by insulin/IGF-1 signaling pathways. Dans Autophagy: Principles, Regulation and Roles in Disease (pp. 181-194). Nova Science Publishers, Inc..

Troncoso, R, Vásquez-Trincado, C, Campo, AD, Gatica, D, Morales, PE, Paredes, F, Torrealba, N, Lopez-Crisosto, C, Pedrozo, Z, Garda, L, Díaz-Araya, G, Battiprolu, PK, Nemchenko, A, Ferdous, A, Gillette, TG, Hill, JA & Lavandero, S 2012, Regulation of autophagy by insulin/IGF-1 signaling pathways. dans Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., pp. 181-194.

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abstract = "Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.",

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AU - Vásquez-Trincado, César

AU - Campo, Andrea Del

AU - Gatica, Damián

AU - Morales, Pablo E.

AU - Paredes, Felipe

AU - Torrealba, Natalia

AU - Lopez-Crisosto, Camila

AU - Pedrozo, Zully

AU - Garda, Lorena

AU - Díaz-Araya, Guillermo

AU - Battiprolu, Pavan K.

AU - Nemchenko, Andriy

AU - Ferdous, Anwarul

AU - Gillette, Thomas G.

AU - Hill, Joseph A.

AU - Lavandero, Sergio

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AB - Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

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BT - Autophagy

PB - Nova Science Publishers, Inc.

ER -

Regulation of autophagy by insulin/IGF-1 signaling pathways

Résumé

ASJC Scopus Subject Areas

ODD de l’ONU

Autres fichiers et liens

Empreinte numérique

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