Basic science of articular cartilage and osteoarthritis

Andrew D. Pearle, Russell F. Warren, Scott A. Rodeo

Résultat de rechercheexamen par les pairs

373 Citations (Scopus)

Résumé

Hyaline cartilage is a highly specialized tissue uniquely designed for load distribution with a smooth, low friction articulating surface. In the homeostatic joint, chondrocyte metabolism maintains a highly structured extracellular matrix that endows cartilage with its biomechanical properties. OA represents a family of disorders characterized by a relentless process in which all components of cartilage are destroyed. It is increasingly clear that this process bridges the biomechanics and biochemistry of cartilage as illustrated by the mechanically mediated and cytokine-mediated pathways involved in the pathogenesis of OA. Further insight into the basic science of cartilage and OA is necessary to develop diagnostic and treatment strategies for this pervasive disease.

Langue d'origineEnglish
Pages (de-à)1-12
Nombre de pages12
JournalClinics in Sports Medicine
Volume24
Numéro de publication1
DOI
Statut de publicationPublished - 2005

ASJC Scopus Subject Areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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Citer

Pearle, A. D., Warren, R. F., & Rodeo, S. A. (2005). Basic science of articular cartilage and osteoarthritis. Clinics in Sports Medicine, 24(1), 1-12. https://doi.org/10.1016/j.csm.2004.08.007