Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases

Javier O. Morales; Sabrina Sepulveda-Rivas; Felipe Oyarzun-Ampuero; Sergio Lavandero; Marcelo J. Kogan

doi:10.2174/1381612821666150901103556

Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases

Javier O. Morales, Sabrina Sepulveda-Rivas, Felipe Oyarzun-Ampuero, Sergio Lavandero, Marcelo J. Kogan

Universidad de Chile

Résultat de recherche › examen par les pairs

7 Citations (Scopus)

Résumé

Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.

Langue d'origine	English
Pages (de-à)	4276-4284
Nombre de pages	9
Journal	Current Pharmaceutical Design
Volume	21
Numéro de publication	29
DOI	https://doi.org/10.2174/1381612821666150901103556
Statut de publication	Published - sept. 1 2015

ASJC Scopus Subject Areas

Pharmacology
Drug Discovery

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.2174/1381612821666150901103556

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abstract = "Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.",

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AU - Sepulveda-Rivas, Sabrina

AU - Oyarzun-Ampuero, Felipe

AU - Lavandero, Sergio

AU - Kogan, Marcelo J.

PY - 2015/9/1

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N2 - Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.

AB - Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.

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Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases

Résumé

ASJC Scopus Subject Areas

ODD de l’ONU

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