Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer

  • Aleksandar Obradovic (Contributor)
  • Diana Graves (Contributor)
  • Michael Korrer (Contributor)
  • Yu Wang (Contributor)
  • Yaomin Xu (Contributor)
  • Adam Luginbuhl (Contributor)
  • Joseph M. Curry (Contributor)
  • Sohini Roy (Contributor)
  • Michael Gibson (Contributor)
  • Paula Hurley (Contributor)
  • Charles Drake (Contributor)
  • Andrea Califano (Contributor)
  • Young Kim (Contributor)

Dataset

Description

RNA-Sequencing Data Associated with the manuscript "Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer." Includes integrated single-cell RNA-Sequencing data & VIPER inferred protein activity matrix uploaded as Seurat Objects with patient and cluster metadata included, as well as sub-clustered fibroblast Seurat object and spatial geomx data. Also includes bulk RNA-Sequencing datasets of responders vs non-responders to treatment and bulk RNA-Sequencing datasets of sorted fibroblast populations used for cluster phenotyping and ex vivo co-culture experiments.
Date made availableDec 15 2021
PublisherMendeley Data

Access Dataset

Cite this

Obradovic, A. (Contributor), Graves, D. (Contributor), Korrer, M. (Contributor), Wang, Y. (Contributor), Xu, Y. (Contributor), Luginbuhl, A. (Contributor), Curry, J. M. (Contributor), Roy, S. (Contributor), Gibson, M. (Contributor), Hurley, P. (Contributor), Drake, C. (Contributor), Califano, A. (Contributor), Kim, Y. (Contributor) (Dec 15 2021). Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer. Mendeley Data. 10.17632/yk8wj7xgdg.1