Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer

  • Aleksandar Obradovic (Contributor)
  • Diana Graves (Contributor)
  • Michael Korrer (Contributor)
  • Yu Wang (Contributor)
  • Yaomin Xu (Contributor)
  • Adam Luginbuhl (Contributor)
  • Joseph M. Curry (Contributor)
  • Sohini Roy (Contributor)
  • Michael Gibson (Contributor)
  • Paula Hurley (Contributor)
  • Charles Drake (Contributor)
  • Andrea Califano (Contributor)
  • Young Kim (Contributor)

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Description

RNA-Sequencing Data Associated with the manuscript "Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer." Includes integrated single-cell RNA-Sequencing data & VIPER inferred protein activity matrix uploaded as Seurat Objects with patient and cluster metadata included, as well as sub-clustered fibroblast Seurat object and spatial geomx data. Also includes bulk RNA-Sequencing datasets of responders vs non-responders to treatment and bulk RNA-Sequencing datasets of sorted fibroblast populations used for cluster phenotyping and ex vivo co-culture experiments.
Date rendue disponibledéc. 15 2021
Maison d'éditionMendeley Data

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Obradovic, A. (Contributor), Graves, D. (Contributor), Korrer, M. (Contributor), Wang, Y. (Contributor), Xu, Y. (Contributor), Luginbuhl, A. (Contributor), Curry, J. M. (Contributor), Roy, S. (Contributor), Gibson, M. (Contributor), Hurley, P. (Contributor), Drake, C. (Contributor), Califano, A. (Contributor), Kim, Y. (Contributor) (déc. 15 2021). Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer. Mendeley Data. 10.17632/yk8wj7xgdg.1