Research Intelligence

2017

Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene) amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl) imino)methine) phenyl)dimethylcarbamothioate

Nuñez, C., Morales, N., García-Beltran, O., Mascayano, C. & Fierro, A., Nov 1 2017, In: Medicinal Chemistry Research. 26, 11, p. 2707-2717 11 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

2015

Iron chelators and antioxidants regenerate neuritic tree and nigrostriatal fibers of MPP+/MPTP-Lesioned dopaminergic neurons

Aguirre, P., Mena, N. P., Carrasco, C. M., Muñoz, Y., Pérez-Henríquez, P., Morales, R. A., Cassels, B. K., Méndez-Gálvez, C., García-Beltrán, O., González-Billault, C. & Núñez, M. T., Dec 1 2015, In: PLoS One. 10, 12, e0144848.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Mechanism study of the thiol-addition reaction to benzothiazole derivative for sensing endogenous thiols

García-Beltrán, O., Santos, J. G., Fuentealba, S., De La Torre, P., Pavez, P., Mena, N., Nuñez, M. T. & Aliaga, M. E., May 6 2015, In: Tetrahedron Letters. 56, 19, p. 2437-2440 4 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

2014

(E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles as efficient Michael acceptors for cysteine: Real application in biological imaging

De La Torre, P., García-Beltrán, O., Tiznado, W., Mena, N., Saavedra, L. A., Cabrera, M. G., Trilleras, J., Pavez, P. & Aliaga, M. E., Mar 31 2014, In: Sensors and Actuators, B: Chemical. 193, p. 391-399 9 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

A coumarinylaldoxime as a specific sensor for Cu²⁺ and its biological application

García-Beltrán, O., Cassels, B. K., Mena, N., Nuñez, M. T., Yañez, O. & Caballero, J., Jan 22 2014, In: Tetrahedron Letters. 55, 4, p. 873-876 4 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

An unusual mulinane diterpenoid from the Chilean plant Azorella trifurcata (Gaertn) Pers

Areche, C., Sepulveda, B., Martin, A. S., Garcia-Beltrán, O., Simirgiotis, M. & Cañete, A., Sept 7 2014, In: Organic and Biomolecular Chemistry. 12, 33, p. 6406-6413 8 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Coumarin-based fluorescent probes for dual recognition of copper(II) and iron(III) ions and their application in bio-imaging

García-Beltrán, O., Cassels, B. K., Pérez, C., Mena, N., Núñez, M. T., Martínez, N. P., Pavez, P. & Aliaga, M. E., Jan 13 2014, In: Sensors. 14, 1, p. 1358-1371 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Citations (Scopus)

Coumarins isolated from Esenbeckia alata (Rutaceae)

García-Beltrán, O., Areche, C., Cassels, B. K. & Cuca Suárez, L. E., Feb 2014, In: Biochemical Systematics and Ecology. 52, p. 38-40 3 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest

Aliaga, M. E., Tiznado, W., Cassels, B. K., Nuñez, M. T., Millán, D., Pérez, E. G., García-Beltrán, O. & Pavez, P., 2014, In: RSC Advances. 4, 2, p. 697-704 8 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies

García-Beltrán, O., Yañez, O., Caballero, J., Galdámez, A., Mena, N., Nuñez, M. T. & Cassels, B. K., Apr 9 2014, In: European Journal of Medicinal Chemistry. 76, p. 79-86 8 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2013

Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe ²⁺

García-Beltrán, O., Mena, N., Yañez, O., Caballero, J., Vargas, V., Nuñez, M. T. & Cassels, B. K., 2013, In: European Journal of Medicinal Chemistry. 67, p. 60-63 4 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

2012

A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells

García-Beltrán, O., Mena, N., Berríos, T. A., Castro, E. A., Cassels, B. K., Núñez, M. T. & Aliaga, M. E., Nov 28 2012, In: Tetrahedron Letters. 53, 48, p. 6598-6601 4 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu ⁺²

García-Beltrán, O., Mena, N., Friedrich, L. C., Netto-Ferreira, J. C., Vargas, V., Quina, F. H., Núñez, M. T. & Cassels, B. K., Sept 26 2012, In: Tetrahedron Letters. 53, 39, p. 5280-5283 4 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety

García-Beltrán, O., González, C., Pérezc, E. G., Cassels, B. K., Santos, J. G., Millán, D., Mena, N., Pavez, P. & Aliaga, M. E., Nov 2012, In: Journal of Physical Organic Chemistry. 25, 11, p. 946-952 7 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Structural reassignment of epierythratidine, an alkaloid from Erythrina fusca, based on NMR studies and computational methods

García-Beltrán, O., Soto-Delgado, J., Iturriaga-Vásquez, P., Areche, C. & Cassels, B. K., 2012, In: Journal of the Chilean Chemical Society. 57, 3, p. 1323-1327 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2011

Erratum: Hydrogen-bonded supramolecular array in the crystal structure of ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate monohydrate (Journal of the Chilean Chemical Society (2011) 56:1 (546-548))

Galdámez, A., García-Beltrán, O. & Cassels, B. K., 2011, In: Journal of the Chilean Chemical Society. 56, 2, p. 724 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study

García-Beltrán, O., Mena, N., Pérez, E. G., Cassels, B. K., Nuñez, M. T., Werlinger, F., Zavala, D., Aliaga, M. E. & Pavez, P., Dec 7 2011, In: Tetrahedron Letters. 52, 49, p. 6606-6609 4 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

2010

Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors

Iturriaga-Vásquez, P., Carbone, A., García-Beltrán, O., Livingstone, P. D., Biggin, P. C., Cassels, B. K., Wonnacott, S., Zapata-Torres, G. & Bermudez, I., Sept 2010, In: Molecular Pharmacology. 78, 3, p. 366-375 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

2009

Crystal structure of (2R, 13bS)-2, 6, 8, 9-tetrahydro-2, 12-dimethoxy-1Hindolo[1-a]isoquinolin-11-ol, C₁₈H₂NO ₃, Erysodine

Iturriaga-Vasquez, P., Garcia-Beltran, O. & Haddow, M. F., 2009, In: Zeitschrift fur Kristallographie - New Crystal Structures. 224, 1, p. 76-78 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Crystal structure of (2R,13bS)-2,6,8,9-tetrahydro-2,12-dimethoxy-1H- indolo [1-α] isoquinolin-11-ol, C₁₈H₂₁NO₃, Erysodine

Iturriaga-Vasquez, P., Garcia-Beltran, O. & Haddow, M. F., Apr 1 2009, In: Zeitschrift fur Kristallographie - New Crystal Structures. 224, 1-4, p. 76-78 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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