A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Aira Muñoz; Sergio Lavandero; Eduardo Donoso; Javier Puente; Mario Sapag-Hagar

doi:10.1016/0014-5793(85)81236-9

A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Aira Muñoz, Sergio Lavandero, Eduardo Donoso, Javier Puente, Mario Sapag-Hagar

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	FEBS Letters
Volume	187
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(85)81236-9
Publication status	Published - Jul 22 1985

Bibliographical note

Funding Information:
This work was supported by grant B 1138-8444 from the Departamento de Desarrollo de la In-vestigacion, Universidad de Chile, and by grant CHI/Sl/OOl from PNUD-UNESCO.

Funding

This work was supported by grant B 1138-8444 from the Departamento de Desarrollo de la In-vestigacion, Universidad de Chile, and by grant CHI/Sl/OOl from PNUD-UNESCO.

Funders	Funder number
Departamento de Desarrollo de la In-vestigacion
PNUD-UNESCO
Universidad de Chile	CHI/Sl/OOl

ASJC Scopus Subject Areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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abstract = "The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.",

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AU - Donoso, Eduardo

AU - Puente, Javier

AU - Sapag-Hagar, Mario

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A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Abstract

Bibliographical note

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ASJC Scopus Subject Areas

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