Resumen
The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.
Idioma original | English |
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Páginas (desde-hasta) | 173-176 |
Número de páginas | 4 |
Publicación | FEBS Letters |
Volumen | 187 |
N.º | 1 |
DOI | |
Estado | Published - jul. 22 1985 |
Financiación
Financiadores | Número del financiador |
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Departamento de Desarrollo de la In-vestigacion | |
PNUD-UNESCO | |
Universidad de Chile | CHI/Sl/OOl |
ASJC Scopus Subject Areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
Huella
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Muñoz, A., Lavandero, S., Donoso, E., Puente, J., & Sapag-Hagar, M. (1985). A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle. FEBS Letters, 187(1), 173-176. https://doi.org/10.1016/0014-5793(85)81236-9