A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Aira Muñoz; Sergio Lavandero; Eduardo Donoso; Javier Puente; Mario Sapag-Hagar

doi:10.1016/0014-5793(85)81236-9

A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Aira Muñoz, Sergio Lavandero, Eduardo Donoso, Javier Puente, Mario Sapag-Hagar

Universidad de Chile

Producción científica › revisión exhaustiva

7 Citas (Scopus)

Resumen

The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

Idioma original	English
Páginas (desde-hasta)	173-176
Número de páginas	4
Publicación	FEBS Letters
Volumen	187
N.º	1
DOI	https://doi.org/10.1016/0014-5793(85)81236-9
Estado	Published - jul. 22 1985

Financiación

This work was supported by grant B 1138-8444 from the Departamento de Desarrollo de la In-vestigacion, Universidad de Chile, and by grant CHI/Sl/OOl from PNUD-UNESCO.

Financiadores	Número del financiador
Departamento de Desarrollo de la In-vestigacion
PNUD-UNESCO
Universidad de Chile	CHI/Sl/OOl

ASJC Scopus Subject Areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(85)81236-9

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title = "A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle",

abstract = "The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.",

author = "Aira Mu{\~n}oz and Sergio Lavandero and Eduardo Donoso and Javier Puente and Mario Sapag-Hagar",

note = "Funding Information: This work was supported by grant B 1138-8444 from the Departamento de Desarrollo de la In-vestigacion, Universidad de Chile, and by grant CHI/Sl/OOl from PNUD-UNESCO.",

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AU - Muñoz, Aira

AU - Lavandero, Sergio

AU - Donoso, Eduardo

AU - Puente, Javier

AU - Sapag-Hagar, Mario

N1 - Funding Information: This work was supported by grant B 1138-8444 from the Departamento de Desarrollo de la In-vestigacion, Universidad de Chile, and by grant CHI/Sl/OOl from PNUD-UNESCO.

PY - 1985/7/22

Y1 - 1985/7/22

N2 - The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

AB - The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

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A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Resumen

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ASJC Scopus Subject Areas

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