Résumé
The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.
Langue d'origine | English |
---|---|
Pages (de-à) | 173-176 |
Nombre de pages | 4 |
Journal | FEBS Letters |
Volume | 187 |
Numéro de publication | 1 |
DOI | |
Statut de publication | Published - juill. 22 1985 |
Financement
Bailleurs de fonds | Numéro du bailleur de fonds |
---|---|
Departamento de Desarrollo de la In-vestigacion | |
PNUD-UNESCO | |
Universidad de Chile | CHI/Sl/OOl |
ASJC Scopus Subject Areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
Empreinte numérique
Plonger dans les sujets de recherche 'A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle'. Ensemble, ils forment une empreinte numérique unique.Citer
Muñoz, A., Lavandero, S., Donoso, E., Puente, J., & Sapag-Hagar, M. (1985). A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle. FEBS Letters, 187(1), 173-176. https://doi.org/10.1016/0014-5793(85)81236-9