A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

Aira Muñoz, Sergio Lavandero, Eduardo Donoso, Javier Puente, Mario Sapag-Hagar

Résultat de rechercheexamen par les pairs

7 Citations (Scopus)

Résumé

The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

Langue d'origineEnglish
Pages (de-à)173-176
Nombre de pages4
JournalFEBS Letters
Volume187
Numéro de publication1
DOI
Statut de publicationPublished - juill. 22 1985

Financement

Bailleurs de fondsNuméro du bailleur de fonds
Departamento de Desarrollo de la In-vestigacion
PNUD-UNESCO
Universidad de ChileCHI/Sl/OOl

    ASJC Scopus Subject Areas

    • Biophysics
    • Structural Biology
    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cell Biology

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    Citer

    Muñoz, A., Lavandero, S., Donoso, E., Puente, J., & Sapag-Hagar, M. (1985). A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle. FEBS Letters, 187(1), 173-176. https://doi.org/10.1016/0014-5793(85)81236-9