Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo; Valentina Parra; Damián Gatica; Andrea E. Rodriguez; Natalia Torrealba; Felipe Paredes; Zhao V. Wang; Antonio Zorzano; Joseph A. Hill; Enrique Jaimovich; Andrew F.G. Quest; Sergio Lavandero

doi:10.1016/B978-0-12-407704-1.00005-1

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao V. Wang, Antonio Zorzano, Joseph A. Hill, Enrique Jaimovich, Andrew F.G. Quest, Sergio Lavandero

Universidad de Chile

Research output: Chapter in Book/Report/Conference proceeding › Chapter

475 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

Original language	English
Title of host publication	International Review of Cell and Molecular Biology
Publisher	Elsevier Inc.
Pages	215-290
Number of pages	76
DOIs	https://doi.org/10.1016/B978-0-12-407704-1.00005-1
Publication status	Published - 2013

Publication series

Name	International Review of Cell and Molecular Biology
Volume	301
ISSN (Print)	1937-6448

Bibliographical note

Funding Information:
We thank the support of Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile: FONDAP 15010006 (S.L., A.Q. and E.J.), Anillo de Investigación de Ciencia y Tecnología ACT1111 (S.L., A.Q. and E.J.), FONDECYT 1120212 (S.L.), FONDECYT 1090071 (A.F.G.Q.). R.B., V.P., D.G., A.E.R. and F.P. hold fellowships from CONICYT, Chile.

Funding

We thank the support of Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile: FONDAP 15010006 (S.L., A.Q. and E.J.), Anillo de Investigación de Ciencia y Tecnología ACT1111 (S.L., A.Q. and E.J.), FONDECYT 1120212 (S.L.), FONDECYT 1090071 (A.F.G.Q.). R.B., V.P., D.G., A.E.R. and F.P. hold fellowships from CONICYT, Chile.

Funders	Funder number
Anillo de Investigación de Ciencia y Tecnología	ACT1111
Comision Nacional de Ciencia y Tecnologia	FONDAP 15010006
Fondo Nacional de Desarrollo Científico y Tecnológico	1120212, 1090071

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-407704-1.00005-1

Cite this

Bravo, R., Parra, V., Gatica, D., Rodriguez, A. E., Torrealba, N., Paredes, F., Wang, Z. V., Zorzano, A., Hill, J. A., Jaimovich, E., Quest, A. F. G., & Lavandero, S. (2013). Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. In International Review of Cell and Molecular Biology (pp. 215-290). (International Review of Cell and Molecular Biology; Vol. 301). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. / Bravo, Roberto; Parra, Valentina; Gatica, Damián et al.
International Review of Cell and Molecular Biology. Elsevier Inc., 2013. p. 215-290 (International Review of Cell and Molecular Biology; Vol. 301).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Bravo, R, Parra, V, Gatica, D, Rodriguez, AE, Torrealba, N, Paredes, F, Wang, ZV, Zorzano, A, Hill, JA, Jaimovich, E, Quest, AFG & Lavandero, S 2013, Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. in International Review of Cell and Molecular Biology. International Review of Cell and Molecular Biology, vol. 301, Elsevier Inc., pp. 215-290. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

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Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Abstract

Publication series

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

Access to Document

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Cite this