Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo; Valentina Parra; Damián Gatica; Andrea E. Rodriguez; Natalia Torrealba; Felipe Paredes; Zhao V. Wang; Antonio Zorzano; Joseph A. Hill; Enrique Jaimovich; Andrew F.G. Quest; Sergio Lavandero

doi:10.1016/B978-0-12-407704-1.00005-1

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao V. Wang, Antonio Zorzano, Joseph A. Hill, Enrique Jaimovich, Andrew F.G. Quest, Sergio Lavandero

Universidad de Chile

Producción científica

467 Citas (Scopus)

Resumen

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

Idioma original	English
Título de la publicación alojada	International Review of Cell and Molecular Biology
Editorial	Elsevier Inc.
Páginas	215-290
Número de páginas	76
DOI	https://doi.org/10.1016/B978-0-12-407704-1.00005-1
Estado	Published - 2013

Serie de la publicación

Nombre	International Review of Cell and Molecular Biology
Volumen	301
ISSN (versión impresa)	1937-6448

Financiación

We thank the support of Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile: FONDAP 15010006 (S.L., A.Q. and E.J.), Anillo de Investigación de Ciencia y Tecnología ACT1111 (S.L., A.Q. and E.J.), FONDECYT 1120212 (S.L.), FONDECYT 1090071 (A.F.G.Q.). R.B., V.P., D.G., A.E.R. and F.P. hold fellowships from CONICYT, Chile.

Financiadores	Número del financiador
Anillo de Investigación de Ciencia y Tecnología	ACT1111
Comision Nacional de Ciencia y Tecnologia	FONDAP 15010006
Fondo Nacional de Desarrollo Científico y Tecnológico	1120212, 1090071

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/B978-0-12-407704-1.00005-1

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Bravo, R., Parra, V., Gatica, D., Rodriguez, A. E., Torrealba, N., Paredes, F., Wang, Z. V., Zorzano, A., Hill, J. A., Jaimovich, E., Quest, A. F. G., & Lavandero, S. (2013). Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. En International Review of Cell and Molecular Biology (pp. 215-290). (International Review of Cell and Molecular Biology; Vol. 301). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

Bravo, R, Parra, V, Gatica, D, Rodriguez, AE, Torrealba, N, Paredes, F, Wang, ZV, Zorzano, A, Hill, JA, Jaimovich, E, Quest, AFG & Lavandero, S 2013, Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. En International Review of Cell and Molecular Biology. International Review of Cell and Molecular Biology, vol. 301, Elsevier Inc., pp. 215-290. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

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Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Resumen

Serie de la publicación

Financiación

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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