Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo; Valentina Parra; Damián Gatica; Andrea E. Rodriguez; Natalia Torrealba; Felipe Paredes; Zhao V. Wang; Antonio Zorzano; Joseph A. Hill; Enrique Jaimovich; Andrew F.G. Quest; Sergio Lavandero

doi:10.1016/B978-0-12-407704-1.00005-1

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao V. Wang, Antonio Zorzano, Joseph A. Hill, Enrique Jaimovich, Andrew F.G. Quest, Sergio Lavandero

Universidad de Chile

Résultat de recherche

456 Citations (Scopus)

Résumé

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

Langue d'origine	English
Titre de la publication principale	International Review of Cell and Molecular Biology
Maison d'édition	Elsevier Inc.
Pages	215-290
Nombre de pages	76
DOI	https://doi.org/10.1016/B978-0-12-407704-1.00005-1
Statut de publication	Published - 2013

Séries de publication

Prénom	International Review of Cell and Molecular Biology
Volume	301
ISSN (imprimé)	1937-6448

Financement

We thank the support of Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile: FONDAP 15010006 (S.L., A.Q. and E.J.), Anillo de Investigación de Ciencia y Tecnología ACT1111 (S.L., A.Q. and E.J.), FONDECYT 1120212 (S.L.), FONDECYT 1090071 (A.F.G.Q.). R.B., V.P., D.G., A.E.R. and F.P. hold fellowships from CONICYT, Chile.

Bailleurs de fonds	Numéro du bailleur de fonds
Anillo de Investigación de Ciencia y Tecnología	ACT1111
Comision Nacional de Ciencia y Tecnologia	FONDAP 15010006
Fondo Nacional de Desarrollo Científico y Tecnológico	1120212, 1090071

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/B978-0-12-407704-1.00005-1

Autres fichiers et liens

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Bravo, R., Parra, V., Gatica, D., Rodriguez, A. E., Torrealba, N., Paredes, F., Wang, Z. V., Zorzano, A., Hill, J. A., Jaimovich, E., Quest, A. F. G., & Lavandero, S. (2013). Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. Dans International Review of Cell and Molecular Biology (pp. 215-290). (International Review of Cell and Molecular Biology; Vol. 301). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

Bravo, R, Parra, V, Gatica, D, Rodriguez, AE, Torrealba, N, Paredes, F, Wang, ZV, Zorzano, A, Hill, JA, Jaimovich, E, Quest, AFG & Lavandero, S 2013, Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. dans International Review of Cell and Molecular Biology. International Review of Cell and Molecular Biology, vol. 301, Elsevier Inc., pp. 215-290. https://doi.org/10.1016/B978-0-12-407704-1.00005-1

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AU - Hill, Joseph A.

AU - Jaimovich, Enrique

AU - Quest, Andrew F.G.

AU - Lavandero, Sergio

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Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Résumé

Séries de publication

Financement

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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