@article{d91c10359aad4d8381fe2e9e7eb72737,
title = "Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes",
abstract = "Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes.",
author = "Paola Navarro and Mario Chiong and Karen Volkwein and Francisco Moraga and Ocaranza, {Mar{\'i}a Paz} and Jalil, {Jorge E.} and Lim, {Sun Woo} and Kim, {Jeong Ah} and Kwon, {H. Moo} and Sergio Lavandero",
note = "Funding Information: We thank Dr. Chris Pogson for his critical reading of the manuscript and Fidel Albornoz for his technical assistance. Funded by Comision Nacional de Ciencia y Tecnolog{\'i}a (CONICYT)—Chile (FONDAP 15010006 to S.L.); NIH DK42479 (to H.M.K.). F.M. holds a Ph.D. fellowship from CONICYT, Chile.",
year = "2008",
month = jul,
day = "25",
doi = "10.1016/j.bbrc.2008.05.067",
language = "English",
volume = "372",
pages = "326--330",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",
}