Universidad de Chile

2016

Mitochondrial dynamics, mitophagy and cardiovascular disease

Vásquez-Trincado, C., García-Carvajal, I., Pennanen, C., Parra, V., Hill, J. A., Rothermel, B. A. & Lavandero, S., Feb 1 2016, In: Journal of Physiology. 594, 3, p. 509-525 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

456 Citations (Scopus)

Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta

Palacios, J., Cifuentes, F., Valderrama, J. A., Benites, J., Ríos, D., González, C., Chiong, M., Cartes-Saavedra, B., Lafourcade, C., Wyneken, U., González, P., Owen, G. I., Pardo, F., Sobrevia, L. & Buc Calderon, P., 2016, In: Oxidative Medicine and Cellular Longevity. 2016, 3939540.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Regulation of cardiomyocyte autophagy by calcium

Shaikh, S., Troncoso, R., Criollo, A., Bravo-Sagua, R., García, L., Morselli, E., Cifuentes, M., Quest, A. F. G., Hill, J. A. & Lavandero, S., Apr 15 2016, In: American Journal of Physiology - Endocrinology and Metabolism. 310, 8, p. E587-E596

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Citations (Scopus)

Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024

Ferreccio, C., Roa, J. C., Bambs, C., Vives, A., Corvalán, A. H., Cortés, S., Foerster, C., Acevedo, J., Huidobro, A., Passi, A., Toro, P., Covacevich, Y., De La Cruz, R., Koshiol, J., Olivares, M., Miquel, J. F., Cruz, F., Silva, R., Quest, A. F. & Kogan, M. J. & 2 others, Castro, P. F. & Lavandero, S., Feb 4 2016, In: BMC Public Health. 16, 1, 122.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Citations (Scopus)

TonEBP suppresses IL-10-mediated immunomodulation

Choi, S. Y., Lee, H. H., Lee, J. H., Ye, B. J., Yoo, E. J., Kang, H. J., Jung, G. W., An, S. M., Lee-Kwon, W., Chiong, M., Lavandero, S. & Kwon, H. M., May 10 2016, In: Scientific Reports. 6, 25726.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

2015

Autophagy in cardiovascular biology

Lavandero, S., Chiong, M., Rothermel, B. A. & Hill, J. A., Jan 2 2015, In: Journal of Clinical Investigation. 125, 1, p. 55-64 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

272 Citations (Scopus)

Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases

Morales, J. O., Sepulveda-Rivas, S., Oyarzun-Ampuero, F., Lavandero, S. & Kogan, M. J., Sept 1 2015, In: Current Pharmaceutical Design. 21, 29, p. 4276-4284 9 p.

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Polycystin-1 is a cardiomyocyte mechanosensor that governs L-type Ca²⁺ channel protein stability

Pedrozo, Z., Criollo, A., Battiprolu, P. K., Morales, C. R., Contreras-Ferrat, A., Fernández, C., Jiang, N., Luo, X., Caplan, M. J., Somlo, S., Rothermel, B. A., Gillette, T. G., Lavandero, S. & Hill, J. A., Jun 16 2015, In: Circulation. 131, 24, p. 2131-2142 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Citations (Scopus)

Regulation of cardiovascular metabolism by hormones and growth factors

Ibarra, C., Lavandero, S. & Estrada, M., 2015, In: International Journal of Endocrinology. 2015, 842351.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Unsaturated fatty acids induce non-canonical autophagy

Niso-Santano, M., Malik, S. A., Pietrocola, F., Bravo-San Pedro, J. M., Mariño, G., Cianfanelli, V., Ben-Younès, A., Troncoso, R., Markaki, M., Sica, V., Izzo, V., Chaba, K., Bauvy, C., Dupont, N., Kepp, O., Rockenfeller, P., Wolinski, H., Madeo, F., Lavandero, S. & Codogno, P. & 7 others, Harpur, F., Pierron, G., Tavernarakis, N., Cecconi, F., Maiuri, M. C., Galluzzi, L. & Kroemur, G., Apr 15 2015, In: EMBO Journal. 34, 8, p. 1025-1041 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Citations (Scopus)

2014

An integrated mechanism of cardiomyocyte nuclear Ca²⁺ signaling

Ibarra, C., Vicencio, J. M., Varas-Godoy, M., Jaimovich, E., Rothermel, B. A., Uhlén, P., Hill, J. A. & Lavandero, S., Oct 1 2014, In: Journal of Molecular and Cellular Cardiology. 75, p. 40-48 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes

Galvis-Pareja, D., Zapata-Torres, G., Hidalgo, J., Ayala, P., Pedrozo, Z., Ibarra, C., Diaz-Araya, G., Hall, A. R., Vicencio, J. M., Nuñez-Vergara, L. & Lavandero, S., Aug 15 2014, In: Toxicology and Applied Pharmacology. 279, 1, p. 53-62 10 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Calcium signaling in insulin action on striated muscle

Contreras-Ferrat, A., Lavandero, S., Jaimovich, E. & Klip, A., Nov 1 2014, In: Cell Calcium. 56, 5, p. 390-396 7 p.

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

Troncoso, R., Paredes, F., Parra, V., Gatica, D., Vásquez-Trincado, C., Quiroga, C., Bravo-Sagua, R., Loṕez-Crisosto, C., Rodriguez, A. E., Oyarzuń, A. P., Kroemer, G. & Lavandero, S., Jul 15 2014, In: Cell Cycle. 13, 14, p. 2281-2295 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Citations (Scopus)

Effects of trimetazidine in nonischemic heart failure: A randomized study

Winter, J. L., Castro, P. F., Quintana, J. C., Altamirano, R., Enriquez, A., Verdejo, H. E., Jalil, J. E., Mellado, R., Concepción, R., Sepúlveda, P., Rossel, V., Sepúlveda, L., Chiong, M., García, L. & Lavandero, S., Mar 2014, In: Journal of Cardiac Failure. 20, 3, p. 149-154 6 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling

Morales, P. E., Torres, G., Sotomayor-Flores, C., Peña-Oyarzún, D., Rivera-Mejías, P., Paredes, F. & Chiong, M., Mar 28 2014, In: Biochemical and Biophysical Research Communications. 446, 1, p. 410-416 7 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy

Xie, M., Kong, Y., Tan, W., May, H., Battiprolu, P. K., Pedrozo, Z., Wang, Z. V., Morales, C., Luo, X., Cho, G., Jiang, N., Jessen, M. E., Warner, J. J., Lavandero, S., Gillette, T. G., Turer, A. T. & Hill, J. A., Mar 11 2014, In: Circulation. 129, 10, p. 1139-1151 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

285 Citations (Scopus)

Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway

Parra, V., Verdejo, H. E., Iglewski, M., Del Campo, A., Troncoso, R., Jones, D., Zhu, Y., Kuzmicic, J., Pennanen, C., Lopez-Crisosto, C., Jaña, F., Ferreira, J., Noguera, E., Chiong, M., Bernlohr, D. A., Klip, A., Hill, J. A., Rothermel, B. A., Abel, E. D. & Zorzano, A. & 1 others, Lavandero, S., Jan 2014, In: Diabetes. 63, 1, p. 75-88 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

188 Citations (Scopus)

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca²⁺-calcineurin signaling pathway

Pennanen, C., Parra, V., López-Crisosto, C., Morales, P. E., del Campo, A., Gutierrez, T., Rivera-Mejías, P., Kuzmicic, J., Chiong, M., Zorzano, A., Rothermel, B. A. & Lavandero, S., 2014, In: Journal of Cell Science. 127, 12, p. 2659-2671 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

147 Citations (Scopus)

Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation

Chiong, M., Cartes-Saavedra, B., Norambuena-Soto, I., Mondaca-Ruff, D., Morales, P. E., García-Miguel, M. & Mellado, R., Dec 15 2014, In: Frontiers in Cell and Developmental Biology. 2, DEC, 72.

Research output: Contribution to journal › Review article › peer-review

Open Access

102 Citations (Scopus)

New insights into IGF-1 signaling in the heart

Troncoso, R., Ibarra, C., Vicencio, J. M., Jaimovich, E. & Lavandero, S., Mar 2014, In: Trends in Endocrinology and Metabolism. 25, 3, p. 128-137 10 p.

Research output: Contribution to journal › Review article › peer-review

191 Citations (Scopus)

Organelle communication: Signaling crossroads between homeostasis and disease

Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales, P. E., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J. A., Simmen, T., Quest, A. F. & Lavandero, S., May 2014, In: International Journal of Biochemistry and Cell Biology. 50, 1, p. 55-59 5 p.

Research output: Contribution to journal › Short survey › peer-review

48 Citations (Scopus)

Oxidative stress and autophagy in cardiovascular homeostasis

Morales, C. R., Pedrozo, Z., Lavandero, S. & Hill, J. A., Jan 20 2014, In: Antioxidants and Redox Signaling. 20, 3, p. 507-518 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

66 Citations (Scopus)

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics

Hahn, W. S., Kuzmicic, J., Burrill, J. S., Donoghue, M. A., Foncea, R., Jensen, M. D., Lavandero, S., Arriaga, E. A. & Bernlohr, D. A., May 1 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 9, p. E1033-E1045

Research output: Contribution to journal › Article › peer-review

Open Access

91 Citations (Scopus)

Reply: Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure

Ocaranza, M. P., Michea, L., Chiong, M., Lavandero, S. & Jalil, J. E., Aug 2014, In: Journal of Hypertension. 32, 8, p. 1719-1721 3 p.

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1

Carrasco, L., Cea, P., Rocco, P., Peña-Oyarzún, D., Rivera-Mejias, P., Sotomayor-Flores, C., Quiroga, C., Criollo, A., Ibarra, C., Chiong, M. & Lavandero, S., Apr 2014, In: Journal of Cellular Biochemistry. 115, 4, p. 712-720 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes

Kuzmicic, J., Parra, V., Verdejo, H. E., López-Crisosto, C., Chiong, M., García, L., Jensen, M. D., Bernlohr, D. A., Castro, P. F. & Lavandero, S., Aug 1 2014, In: Biochemical Pharmacology. 91, 3, p. 323-336 14 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Tumor Suppression and Promotion by Autophagy

Ávalos, Y., Canales, J., Bravo-Sagua, R., Criollo, A., Lavandero, S. & Quest, A. F. G., 2014, In: BioMed Research International. 2014, 603980.

Research output: Contribution to journal › Review article › peer-review

Open Access

149 Citations (Scopus)

2013

Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death

Parra, V., Moraga, F., Kuzmicic, J., López-Crisosto, C., Troncoso, R., Torrealba, N., Criollo, A., Díaz-Elizondo, J., Rothermel, B. A., Quest, A. F. G. & Lavandero, S., Aug 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1334-1344 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy

Pedrozo, Z., Torrealba, N., Fernández, C., Gatica, D., Toro, B., Quiroga, C., Rodriguez, A. E., Sanchez, G., Gillette, T. G., Hill, J. A., Donoso, P. & Lavandero, S., May 1 2013, In: Cardiovascular Research. 98, 2, p. 277-285 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Citations (Scopus)

Cardiovascular autophagy Concepts, controversies, and perspectives

Lavandero, S., Troncoso, R., Rotherme, B. A., Martinet, W., Sadoshima, J. & Hill, J. A., Oct 2013, In: Autophagy. 9, 10, p. 1455-1466 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

152 Citations (Scopus)

Cell death and survival through the endoplasmic reticulum-mitochondrial axis

Bravo-Sagua, R., Rodriguez, A. E., Kuzmicic, J., Gutierrez, T., Lopez-Crisosto, C., Quiroga, C., Díaz-Elizondo, J., Chiong, M., Gillette, T. G., Rothermel, B. A. & Lavandero, S., 2013, In: Current Molecular Medicine. 13, 2, p. 317-329 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

92 Citations (Scopus)

Diabetic cardiomyopathy and metabolic remodeling of the heart

Battiprolu, P. K., Lopez-Crisosto, C., Wang, Z. V., Nemchenko, A., Lavandero, S. & Hill, J. A., 2013, In: Life Sciences. 92, 11, p. 609-615 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

77 Citations (Scopus)

Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells

Osorio-Fuentealba, C., Contreras-Ferrat, A. E., Altamirano, F., Espinosa, A., Li, Q., Niu, W., Lavandero, S., Klip, A. & Jaimovich, E., May 2013, In: Diabetes. 62, 5, p. 1519-1526 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Citations (Scopus)

Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells

Antileo, E., Garri, C., Tapia, V., Muñoz, J. P., Chiong, M., Nualart, F., Lavandero, S., Fernández, J. & Núñez, M. T., 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 7, p. G655-G661

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Bravo, R., Parra, V., Gatica, D., Rodriguez, A. E., Torrealba, N., Paredes, F., Wang, Z. V., Zorzano, A., Hill, J. A., Jaimovich, E., Quest, A. F. G. & Lavandero, S., 2013, International Review of Cell and Molecular Biology. Elsevier Inc., p. 215-290 76 p. (International Review of Cell and Molecular Biology; vol. 301).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

462 Citations (Scopus)

Erratum: Mitochondrial control of cell death induced by hyperosmotic stress (Apoptosis (2007) 12:3 DOI: 10.1007/s10495-006-0328-x)

Criollo, A., Galluzzi, L., Chiara Maiuri, M., Tasdemir, E., Lavandero, S. & Kroemer, G., Apr 2013, In: Apoptosis : an international journal on programmed cell death. 18, 4, p. 535-536 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Herp depletion protects from protein aggregation by up-regulating autophagy

Quiroga, C., Gatica, D., Paredes, F., Bravo, R., Troncoso, R., Pedrozo, Z., Rodriguez, A. E., Toro, B., Chiong, M., Vicencio, J. M., Hetz, C. & Lavandero, S., 2013, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 3295-3305 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Influence of glucose metabolism on vascular smooth muscle cell proliferation

Chiong, M., Morales, P. E., Torres, G., Gutiérrez, T., García, L., Ibacache, M. & Michea, L., Jan 2013, In: Vasa - European Journal of Vascular Medicine. 42, 1, p. 8-16 9 p.

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors

Ibarra, C., Vicencio, J. M., Estrada, M., Lin, Y., Rocco, P., Rebellato, P., Munoz, J. P., Garcia-Prieto, J., Quest, A. F. G., Chiong, M., Davidson, S. M., Bulatovic, I., Grinnemo, K. H., Larsson, O., Szabadkai, G., Uhlén, P., Jaimovich, E. & Lavandero, S., Jan 18 2013, In: Circulation Research. 112, 2, p. 236-245 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Citations (Scopus)

Regulation of cardiac autophagy by insulin-like growth factor 1

Troncoso, R., Díaz-Elizondo, J., Espinoza, S. P., Navarro-Marquez, M. F., Oyarzún, A. P., Riquelme, J. A., Garcia-Carvajal, I., Díaz-Araya, G., García, L., Hill, J. A. & Lavandero, S., Jul 2013, In: IUBMB Life. 65, 7, p. 593-601 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Signaling in cell death, survival, proliferation and degeneration

Smaili, S. S., Quest, A. F. G., Hetz, C. & Lavandero, S., 2013, In: Current Molecular Medicine. 13, 2, p. 239-240 2 p.

Research output: Contribution to journal › Editorial › peer-review

Testosterone increases GLUT4-Dependent glucose uptake in cardiomyocytes

Wilson, C., Contreras-Ferrat, A., Venegas, N., Osorio-Fuentealba, C., Pávez, M., Montoya, K., Durán, J., Maass, R., Lavandero, S. & Estrada, M., Dec 2013, In: Journal of Cellular Physiology. 228, 12, p. 2399-2407 9 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways

Vivar, R., Humeres, C., Ayala, P., Olmedo, I., Catalán, M., García, L., Lavandero, S. & Díaz-Araya, G., Jun 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 6, p. 754-762 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Citations (Scopus)

2012

A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway

Zamorano, S., Rojas-Rivera, D., Lisbona, F., Parra, V., Court, F. A., Villegas, R., Cheng, E. H., Korsmeyer, S. J., Lavandero, S. & Hetz, C., Jun 12 2012, In: PLoS One. 7, 6, e37782.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Citations (Scopus)

Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes

Bustamante-Marín, X., Quiroga, C., Lavandero, S., Reyes, J. G. & Moreno, R. D., Jun 2012, In: Apoptosis : an international journal on programmed cell death. 17, 6, p. 539-550 12 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

Ayala, P., Montenegro, J., Vivar, R., Letelier, A., Urroz, P. A., Copaja, M., Pivet, D., Humeres, C., Troncoso, R., Vicencio, J. M., Lavandero, S. & Díaz-Araya, G., Feb 2012, In: Experimental and Molecular Pathology. 92, 1, p. 97-104 8 p.

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Cardiac plasticity in health and disease

Gondalia, R. B., Rothermel, B. A., Lavandero, S., Gillette, T. G. & Hill, J. A., Jan 1 2012, Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques. Humana Press Inc., p. 185-250 66 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart

Ibacache, M., Sanchez, G., Pedrozo, Z., Galvez, F., Humeres, C., Echevarria, G., Duaso, J., Hassi, M., Garcia, L., Díaz-Araya, G. & Lavandero, S., Apr 2012, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 4, p. 537-545 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Citations (Scopus)

Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast

Catalán, M., Smolic, C., Contreras, A., Ayala, P., Olmedo, I., Copaja, M., Boza, P., Vivar, R., Avalos, Y., Lavandero, S., Velarde, V. & Díaz-Araya, G., Jun 15 2012, In: Toxicology and Applied Pharmacology. 261, 3, p. 300-308 9 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Universidad de Chile

Research output

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